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Last Updated July 28, 2016
Gluten Syndrome
Laboratory Test Panels
and
Test Panels which Target Villi Damage only (Celiac disease)
Panels are in alphabetical
order by Laboratory or Celiac center name.
This website has no
financial interest in any products or services mentioned here.
Cyrex Labs is now open!
click here. More
info asap.
www.cyrexlabs.com
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NOTE: Evidence of
the gluten syndrome can be hard to find. It hides very well often!
Some researchers believe
no one test panel covers all possibilities.
Gluten can break down into pieces for which there are no tests at this
time.
Patients who wish to "leave no known stone unturned" must be prepared to
run several types of tests, methodically checking all
markers, systems and mediums until they exhaust all known possibilities.
There are several known toxic gluten fractions for which no tests are
available at this time.
Research on these markers.
Some researchers also believe that disturbances***
may block the markers for which
these tests are looking. They also believe the
body may be too exhausted to even properly
process the proteins needed to make very many antibodies. Therefore, if
a negatively tested patient still suspects a gluten related reaction,
the patient is wise to seriously respect his body's message.
Panels on this page test for various combinations of the following known markers, in
the following body systems, in the following mediums:
Gluten Syndrome Antibody Markers Body Immune Systems*
Mediums
*Gliadin (a "piece" of gluten) AGA - Anti
Gliadin Antibodies IgA, IgG, IgM, ALCAT
Blood (serum), Stool, Saliva
UPDATE:
8
more forms of gliadin antibodies are now available for testing by Cyrex
Labs
Gluten (Whole gluten molecule - rarely tested - WHY NOT!!)
IgA, IgG, IgM
Blood
UPDATE: Gluten(in) now available by Cyrex Labs
IgA, IgG
Blood
Gluteomorphin (a toxic
opiate like piece of improperly digested gluten) IgA, IgG, IgM, ALCAT
Blood
UPDATE: Gluteomorphin antibody tests available by Cyrex Labs
tTG (tissue transglutaminase - elevation indicates gut damage) IgA, IgG, IgM, ALCAT Blood, Stool,
Saliva
EMA (anti endomysial antibodies - replaced by tTG) IgA, IgG,
Blood
Wheat (whole kernel, to test unknown factors)
IgA, IgG
Blood
UPDATE: Wheat and wheat germ antibody tests available by Cyrex
Labs
IgA, IgG
Blood
Overall Intestinal Function (fat malabsorption) Molecule size, Stool
Genes - HLA DQ 2, 8 only -
reported positive/negative Blood or cheek swab
OR
your HLA DQ type is reported
Some researchers also recognize HLA DQ 1 and 3 and others.
Some believe genes are not needed in all cases, and blame toxins, stress and infections as
underlying causes due to leaky gut or breached mucosal membranes.
membranes)
Non Antibody markers
Urine tests for
gluteomorphin peptides (not the antibodies to
gluteomorphins, but the peptides/pieces of gluten themselves) are
available from Genova Diagnostics (Urinary Polypeptides panel), and
Great Plains Laboratories (Gluten and Casein Peptides)
Some blood test panels do not look for
antibodies. Instead they react the blood with various substances
(antigens), in this case gluten related antigens and look for changes in
the white cells or specific white cells called lymphocytes that may
indicate an immune response. These changes may be swelling,
granulation, apoptosis, halos, etc. These tests are controversial.
Some professionals believe they pick up foods the person eats frequently, not
necessarily ones to which they have an immune response. Some
patients believe the test help them identify problem foods.
*
Most labs now run "deamidated gliadin" which is considered more
likely to be positive if an immune response is present.
Cross reactive foods
Additionally, some labs test for known
cross
reactive foods and other potentially problematic substances, gluten grain
substitutes/foods and organs/tissues most prone to
gluten damage due to their similar protein structure. Cross
reactive food include
Milk, (casomorphins, butyrophilins) - the peptides themselves and IgA, IgG, IgM
antibodies
Egg - IgA, IgG, IgM
Corn - IgA, IgG, IgM,
Soy - IgA, IgG, IgM,
Yeasts
Barley, and Rye are considered gluten
grains.
Spelt, Durum wheat, Polish wheat, Kamut,
Fu, are forms of wheat.
Buckwheat, Sorghum, Amaranth, Tapioca,
Potato, Rice, Hemp, are considered gluten free, but may also cross react
in some people.
Oats are considered gluten free if produced
in a gluten free environment and marked as such. Many folks react to GF
oats.
Sometimes coffee, chocolate, and sesame may
also cross react.
Note: Quinoa, buckwheat, millet, sorghum, and other non gluten grains are
now suspected to be problematic for some patients**. It may be
helpful to test gluten substitutes also. Some researchers believe that
if the gut is still "leaky" (meaning it allows substances to cross the
gut wall before they are sufficiently broken down), the body may become
reactive to more substances including gluten substitutes.
Tissue damage tests and biopsies
Villi focused celiac specialists use villi and skin biopsies as
gold standards to diagnose an immune reaction to gluten and only then to prescribe the gluten
free diet.
Gluten syndrome specialists do NOT use the villi biopsy
for gold standard gluten syndrome diagnosis but may utilize the endoscopy
if there are other reasons to examine the gut. Often, since they
are already there, they take a biopsy to check, but ignore a
negative biopsy diagnostic since the villi may be healthy but other
tissues in other places may be the targets of damage instead. To
look for tissue damage in other places that are not easily biopsied,
gluten syndrome specialists rely instead on organ/tissue function tests and
soon predictive
organ/tissue antibody tests to check for possible organ or tissue damage,
coupled with gluten antibody tests. If the patient has gluten
antibodies, a gluten free diet and other treatments are prescribed and
the tissue antibodies are rechecked later for possible improvement.
Here are common tissue antibody tests that
indicate organ damage is ongoing.
Brain and nervous system - Myelin basic
protein (MBP), cerebellar tissue and neurofilaments - IgA, IgG, IgM
Thyroid - Thyroid peroxidase, Thyroglobulin - IgA, IgG, IgM
Pancreas - Glutamic Acid Decarboxylase
- IgA, IgG, IgM
Stomach - Parietal cells (B 12 function) -
IgA, IgG, IgM
Heat Shock Proteins
DPP IV - Digestive enzyme that breaks down
gluten and milk
Gene tests
The "celiac only" perspective on genes
According to most researchers, gene tests
are not proof that the immune system presently reacts. They do
indicate a predisposition for gluten reaction. Celiac focused
specialists recognize HLA DQ 2, and 8 for celiac predisposition.
Other genes in other locations are under investigation.
The most complete gene tests are run in 2
parts.
Most
celiac focused gene tests do not report the patient's actual HLA DQ
genes. They only report positive or negative for HLA DQ 2 or 8.
If they are positive some labs will provide the specific 2 or 8 gene
subtype upon request.
These tests can run from $400 - $500 and may be much higher if
they are ordered through a hospital or celiac center.
The "gluten syndrome" perspective on
genes
Dr. Ken Fine, MD, Enterolab, Dallas, Tx,
recognizes HLA DQ 1, 2, 3, and 8 as gluten syndrome associated genes. He
states that HLA DQ 4 is the only HLA gene that does not appear to be
related to gluten reaction. According to Dr. Fine this translates
to about 83% of the Caucasian population as gluten syndrome gene
carriers.
https://www.enterolab.com/StaticPages/Faq_Result_Interpretation.htm
Enterolab reports the actual HLA DQ genes the patient possesses, not just positive or negative
for HLA DQ 2 or 8. Enterolab only runs a 1 part gene test , not the second
part for certain few DQ 2 subtypes. Why?
Here is an explanation. This
gluten syndrome related gene test
is $169.
Dr. Fine believes that if gluten is presented to the immune system,
meaning if it slips, improperly digested, beyond a mucosal barrier such
as the gut wall, the immune system will always react if a gluten
syndrome gene is present.
Dr. Fine's work is highly respected for
it's clinical accuracy, but to date is unpublished. (Jan, 2011)
Dr. Aristo Vojdani, Los Angeles, CA, does
not believe a gene is necessary for immune response to gluten, but if it
is present it
does predispose. He believes TOXINS, in particular,
(and stress and
infections) are sufficient to trigger immune response without a gluten
related gene. He considered HLA DQ 2 and 8 only when he came
to this conclusion.
Additional factors and comments
The more markers tested in
the most places in the body, in the most mediums, the higher the chance
of finding evidence somewhere in the body of an adverse reaction to
gluten. There is no guaranteed order of testing priority.
Patients who test extensively and become convinced that they are not
gluten reactive may develop gluten reactivity in the future, often
triggered by stressors, toxins, or infections. According to some
researchers, genes are not needed but can predispose to adverse
reaction.**
Some patients go gluten free simply because they believe gluten is not
good for anyone due to changes in gluten grains and other health issues
today. Without test confirmation, it is more difficult to
establish and maintain a lifelong strict gluten free diet.
Some
patients will not find confirmation with the incomplete tests available
today.
FYI !! Seesawing on and off a gluten
free diet may trigger painful and/or atypical reactions in some people,
including neurological symptoms.
For a few patients, going gluten free may
trigger a temporary withdrawal reaction, similar to a drug withdrawal,
with a
variety of symptoms.
The hypersensitive immune system
Some professionals believe the immune system may still be too hypersensitive (runs in "high gear") even
on the gluten free diet.
They believe it needs to be "shifted back into neutral" to avoid continued
overreaction and autoimmune damage. Many doctors believe this may
involve other lifestyle changes beside going gluten free. Many
patients also choose to reduce or avoid toxins, sugars, grains in
general, processed fats and food, electromagnetic radiations. They
switch to more nutrient dense organic, pastured animal foods and
sometimes some raw
foods, and simplify their lives to avoid stress.
For a specific protocol to intended to calm
down the immune system, see www.thedr.com
* IgA, IgG, IgM are different parts of the immune system
ALCAT tests the white blood cell reaction to various substances.
It is not an antibody test.
ELISA ACT panels test the B cells within which the antibodies are made.
This is not an antibody test.
** Dr. Aristo Vojdani PhD, MT, Immunosciences Laboratories, (researcher)
***
Dr. Dietrich Klinghardt, MD, PhD Disturbances may include emotions
and body electric issues in some investigators opinions
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More info here asap.
Cyrex labs now offers detailed antibody
panels for gluten, gluteomorphins, and many other gluten related
antibodies, cross reactive foods and intestinal permeability in saliva
and blood.
If these extensive tests still produce a
suspicious negative, a stool test (very sensitive for gliadin and tTG)
from www.enterolab.com is a separate option to check, OR the patient may
react to antibodies for which no tests are currently developed.
Note: the Enterolab stool test is the only test available that is useful
for someone who has been on a gluten free diet for months. Call
the lab to find out how long GF is too long to use the stool test.
www.enterolab.com
For such extreme negative testing patients,
an elimination diet may give them information. How long is long enough?
There is no final answer. This is not an easy situation, but
likely rare. However, if there is no definite reaction to
removing gluten, challenging an elimination diet with gluten should be
done carefully under a knowledgeable doctor's care, and discontinued if
there is a reaction. In these cases it is important to remember
silent syndrome dynamics that may silence nerves and mask
improvement or further damage upon challenge.
In a high percentage of cases when patients
are tested for additional antibodies in more mediums such as stool,
blood and saliva, many more of of
them obtain positive results. (ex., in one practice, 77% of patients
tested positive to a detailed panel of gluten related antibodies
similar to the extensive panel now offered by Cyrex Labs.)
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Click to go directly to a specific lab
ALCAT Worldwide Cell Science Systems
Chicago - University of Chicago Celiac Disease
Program
Columbia - Celiac Disease Center at Columbia
University
Cyrex Labs
Direct Lab Services
Enterolab
Genova Diagnostics - formerly Great Smokies
Laboratories
HealthLabs.com
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Immco Diagnostics
Immunosciences Laboratories
- see Cyrex Labs
Kimball Genetics
Mayo Clinic
Maryland - University of Maryland Center for Celiac
Research
National Digestive Diseases Information
Clearinghouse
Optimum Health Resources Labs - (formerly York
Allergy Labs)
Prometheus Laboratories |
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ALCAT Worldwide Cell Science Systems
www.alcat.com
email: info@alcat.com
1239
East Newport Center Drive, Suite 101
Deerfield Beach, FL 33442
Phone:
(800) US AL CAT (872-5228) (954) 426 - 2304 Fax:
(954)428-8676
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The ALCAT test is a separate
type of test compared to the antibody panels featured on this page.
This test does not check antibodies. In this method, white blood cells
are exposed to various foods and substances and the reaction of the
white blood cells, such as swelling, granulation, etc., is observed. Adverse white blood cell reactions may occur for many
reasons. The test process does not indicate why the response occurs
or if it is autoimmune. It is only believed by some to indicate that there is an adverse reaction. It
does NOT rule out other types of reactions such as antibody formation or
processes science has not yet discovered. For more
information see
www.alcat.com
This test is controversial.
Many professionals believe it is not scientifically reliable and will simply show positive for foods eaten
frequently. Many patients claim the results help them pinpoint
problem foods but not necessarily gage the severity of the reaction.
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Here is a simple analogy to explain
the difference between the ALCAT test and
traditional blood or stool tests for IgM, IgG and IgA antibodies. To
look for antibodies in the IgA, IgG or IgM systems is similar to calling in the Army, Navy and Air Force to find a
criminal.
(See "Stories to Help Us Understand" on
the "Testing" page). The
ALCAT method is likened to calling in the National Guard. It's
claimed to be another place to look for proof of adverse response. As
with antibody tests, a positive ALCAT test is thought to be proof of a problem, but a
negative test does NOT guarantee the substance is safe since OTHER BODY
SYSTEMS MAY REACT. |
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Panels range from 50
items tested to over 200. Prices range from $87.50 - $999
This lab includes
gliadin ( a part of wheat
gluten)
and gluten tests
in their panels. They also test separately for barley, rye and other
grains. Doctor prescription is not mandatory and arrangements are
available for a mobile nurse/phlebotomist to perform the blood draw at
home. Post test counseling is included in the test package.
This is the only blood test available for patients who have been strictly
gluten free for a very long time.
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Chicago, University of - The
University of Chicago Celiac Disease Program
Founder/Medical Director - Dr. Stefano Guandalini
Program
Director - Carol McCarthy Shilson
5839 S. Maryland Avenue, MC 4069, Room C-491
Chicago, IL 60637
Phone - 773-702-7593
Website www.celiacdisease.net
This panel focuses on celiac villi damage only.
 Celiac Disease Screener tTG-IgA
(specific to villi damage)  Gene test
Additional options EMA -IgA, and/or
Total IgA
This is a panel recommended by University of Chicago Celiac Disease
Program. This is not a commercial lab.
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There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
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Gluten Syndrome focused
researchers believe -
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antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
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there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
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Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
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Celiac (villi damage focused)
specialists believe -
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Columbia, University of - Celiac
Disease Center at Columbia University
Dr. Peter H. R. Green MD - Director
For general education and information contact Hal
Winfield Phone 212-342-0251
Website - www.celiacdiseasecenter.columbia.edu
This is a short non
comprehensive antibody panel.
Celiac Disease Panel
Gene test 
Intestinal duodenal biopsy
 Skin Biopsy
This panel is recommended by
the Columbia Celiac Disease Center. This is not a commercial lab
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There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
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Gluten Syndrome focused
researchers believe -
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antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
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there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
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Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
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Celiac (villi damage focused)
specialists believe -
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Cyrex Labs
Cyrex Labs now offers comprehensive gluten syndrome testing
formerly performed by Immunosciences Laboratories.
Immunosciences Laboratories is currently a specialty retail and research lab.
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Medical Director - Dr. Dhiren Joshipura, M.D.
Chief Scientific Advisor - Dr. Aristo Vojdani, Ph.D.,
M.Sc., C.L.S. of Immunosciences Laboratories
Clinical Advisor Functional Medicine - Dr. Thomas O’Bryan, D.C., C.C.N.,
D.A.C.B.N. www.thedr.com
Video clips of Dr. Vojdani
Part 1 Quicktime
Dialup,
DSL Windows Media
Dialup,
DSL
Part 2
Quicktime
Dialup,
DSL Windows Media,
Dialup,
DSL
5040 N. 15th Ave. Suite 107
Phoenix, AZ, 85015
Questions? email
here
Phone: (602)-759-1245
Fax (602) 7597-8331
Research articles available at
www.thedr.com
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Cyrex
Labs,i
Mediumsttested:
Saliva
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Sensitive GliadiniSalivaiScreener
Antibody Array 1
Available from your practitioner
or $150 from
www.thedr.com |
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IgE |
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IgG |
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IgM |
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NEW! Gluten
Sensitivity Screen Array 1 - Saliva Home Collection Test
Secretory IgA
Tests deamidated gliadin - IgA, IgM,
tTG - IgA, IgM
Price: $150.00 if ordered from
www.thedr.com
Patients may order test
with script
here
Many patients start with the economical, and
fairly sensitive saliva screener, Array 1, first. If the patient
makes these particular antibodies, this test is claimed to have a 96%
sensitivity to find them. This means out of 100 samples it will accurately
pick up 96 of them if they are present in the sample.
If the saliva screener is negative, the
patient has the option to order the more comprehensive antibody blood
panel, array 3. Or they may order both panels to begin with to
"cover the most possible bases" since the two tests check mostly different
antibodies in different mediums.
NOTE: While the saliva test is quite
sensitive for the antibodies it checks, it will be negative
if patient has different gluten related antibodies besides the ones this
saliva test checks. Furthermore, research indicates that tTG is not
elevated in all cases of the gluten syndrome. Research shows that
tTG is only consistently elevated in cases of severe tissue damage to
intestinal villi damage. Note that elevated tTG does not appear in the gluten intolerance diagram on the
Medical Diagrams page and
The Immunology of Immediate and Delayed Hypersensitivity to Gluten
article.
Full text here
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Cyrex Labs
Medium tested:
Blood |
Intestinal Antigenic
Permeability Screen -
Antibody
Array 2
Available from your practitioner or
$230 from
www.thedr.com |
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IgA |
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IgG |
x |
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IgM |
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NEW!
Intestinal
Antigenic Permeability Screen
Actomyosin - IgG,
Occludin/Zonulin - IgA, IgG, IgM
Lipopolysaccharides i(LPS)
- IgA, IgG, IgM
This screener checks the permeability of the intestinal wall. This
test looks for sufficient gut damage that molecules large enough to set
off the immune system can cross the gut wall.
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Cyrex
Labs,i
Mediumsttested:
Bloodi
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Wheat/GluteniProteome
Sensitivity
and Autoimmunity - Antibody Array 3
Available from your practitioner
or $360 from
www.thedr.com |
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IgA |
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GeneiHLAiDQi2,,8
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The gluten antibodies in this
recommended blood panel are the most
complete list offered for
tests developed and available at this time.
IgM antibodies for these same
peptides may be added at a later date.
IgM Antibodies may be
necessary to check if "Activation Induced Cytidine Deaminase" (AID),
an enzyme, is not functioning
properly.
(Note: the saliva
screener, Array 1, below, checks 2 IgM antibodies.)
NEW!
This array checks the following antibodies as shown in the chart above
Glutenin (Gluten) - IgA
and IgG
Gluteomorphins -
IgA and IgG
Alpha Gliadin 17 MER -
IgA and IgG
Alpha Gliadin33 MER -
IgA and IgG
Gamma Gliadin 15 MER -
IgA and IgG
Omega Gliadin -
IgA and IgG
Gliadin-Transglutaminase
- IgA and IgG
tTG - Tissue Transglutaminase
- IgA and IgG
Glutamic Acid Decarboxylase
- IgA and IgG
Prodynorphin -
IgA and IgG
Wheat - IgA and
IgG
Wheat Germ Agglutinin -
IgA and IgG
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Gluten Associated Sensitivity and Cross
Reactive Foods
Antibody Array 4
IgA and IgG Combined
Order through your practitioner
or $260 from
www.thedr.com |
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Cow's Milk |
x |
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Alpha Casein and Beta
Casein |
x |
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Casomorphins |
x |
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Milk Butyrophilins |
x |
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American Cheese |
x |
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Chocolate |
x |
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Sesame |
x |
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Hemp |
x |
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Rye |
x |
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Barley |
x |
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Polish Wheat |
x |
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Buckwheat |
x |
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Sorghum |
x |
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Millet |
x |
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Spelt |
x |
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Amaranth |
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Quinoa |
x |
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Yeast |
x |
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Tapioca |
x |
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Oats |
x |
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Coffee |
x |
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Corn |
x |
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Rice |
x |
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Potato |
x |
This panel checks: Foods that most often cross react with gluten
Food most often used as gluten free substitutes.
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These are the most
comprehensive Gluten Syndrome
and Cross Reactive/Substitute
Foods Panels available
Coming:
Predictive antibody tissue damage tests
to find targeted areas of
autoimmune damage.
A gluten (or other food)
containing diet is required for the any of the food antibody tests.
Dr. Script required.
See
www.thedr.com
if you do not have a practitioner to write the script and interpret the
results.
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Immune response to dietary proteins,
gliadin and cerebellar peptides in children with autism.
Nutr Neurosci.
2004 Jun;7(3):151-61.Vojdani
A,
O'Bryan T,
Green JA,
Mccandless J,
Woeller KN,
Vojdani E,
Nourian AA,
Cooper EL.
Section of Neuroimmunology, Immunosciences
Lab., Inc., 8693 Wilshire Blvd., Ste. 200, Beverly Hills, California
90211, USA.
drari@msn.com
Full text here
Infections, toxic chemicals and dietary peptides
binding to lymphocyte receptors and tissue enzymes are major instigators
of autoimmunity in autism.
Int J Immunopathol Pharmacol.
2003 Sep-Dec;16(3):189-99
Vojdani A,
Pangborn JB,
Vojdani E,
Cooper EL
Lab. Comparative
Immunology, Dept. Neurobiology, UCLA Medical Center, Los Angeles, CA, USA.
DrAri@msn.com
Full Text
here
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In Celiac Disease, A
Subset of Autoantibodies against Transglutaminase Binds Toll-Like Receptor 4
and Induces Activation of Monocytes
Published Sept 19, 2006
Giovanna Zonomi1, Niccardo Navone2, Claudio Lunardi2,
Giuseppe Tidente1, Carerina Bason2, Simona Sivori3,
Buggero Beri2 Marzia Dolcino4, Enrico Valletta5,
Roberto Corrocher2, Antonio Puccetti3,4
Click for
abstract and full text
1. Section of Immunology, Department of Pathology, Universtiy of Verona,
Verona, Italy,
2. Section of Internal Medicine, Department of Clinical and Experimental
Medicine, University of Verona, Verona, Italy
3. Section of Histology, Departmant of Experimental Medicine, University of
Genova, Genova, Italy
4. Immunology Unit, Institute G. Gaslini, Genova, Italy,
5. Department of Pediatrics, University Hospital of Verona, Verona, Italy
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NEW!
The Immunology of
Immediate and Delayed Hypersensitivity to Gluten - European
Journal of Inflammation Vol 6 No. 1 1-10 (2008) Editorial - A. Vojdani
Beverly Hills, CA
(now Los Angeles, CA) T. O'Bryan, Warrenville, IL,( now Chicago, Il), G.
H. Kellermann Neuroscience, WI, USA
Full text here
Note: This file contains 2 articles from the
journjournal.
Scroll to the top to find the Vojdani article
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NEW!
The Immunology of Gluten
Sensitivity Beyond the Intestinal Tract - European Journal of
Inflammation Vol 6 No 2, 0-0 (2008) Aristo Vojdani, PH.D, M.T., Thomas
O'Bryan,
D.C.
D.C.,
CCN,
DACBN
Full text here
-
NEW!
The Gluten
Response in Children with Celiac Disease is Directed toward Multiple
Gliadin and Glutenin Peptides - Willemijen Vader, Yvonne Kooy, Peter
Van Veelen,
Arnoud de Ru, Diana Harris, Willemien Benckhuijsen, Salvador Pena, Luisa
Mearin, Jan Wouter Drijfhout, and Frits Koning Departments of
Immunohematology and
Blood Transfusion and Paediatrics, Leiden University Medical Centre,
Leiden, The Netherlands; and the Free University, Amsterdam, The
Netherlands
Gastroenterology 2002; 122:1729-1737
Full text here
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe, based on published research -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the gluten free
diet. They do NOT recommend villi biopsy unless there are other
reasons to examine the gut. They use other comprehensive blood test
panels to find multiple tissue and function damage instead of focusing on
only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
Published research shows tTG is only consistently elevated in cases of
very severe tissue damage to intestinal villi.
|
|
Celiac (villi damage focused)
specialists believe -
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|
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Can't get a doctor to listen or prescribe testing?
This lab provides direct testing services through
local Patient Service Centers.
An on staff DLS physician provides the script.
These are not comprehensive
panels.
Direct Lab Services
Mailing Address:
P.O. Box 601
Mandeville, LA 70470-0601
Street Address:
300 Mariners Plaza
Suite 320
Mandeville, LA 70448
Local: 985-624-9186 Local Fax: 985-626-4020
Toll-Free : 1-800-908-0000 Toll-Free
Fax:
1-800-728-9048
Email:
contact@directlabs.com
website:
www.directlabs.com
Direct Lab Services offers 3 gluten
related panels without a prescription from the patient's doctor.
A staff physician provides the script.
The specimen is drawn at a local LabCorp location.
Celiac panels are found under the
"testing" link in the alphabetical list
Celiac Disease Ab Profile
Price: $192
Celiac Disease AB Comprehensive Profile
Price: $220
~~~~
Immuno Labs tests available through Direct
Lab Services are found under the Tests > Specialty Labs > Immuno Labs link
on the Direct Labs website
Immuno Labs AGA - IgA, IgG
Price: $152 Includes
Comprehensive Metabolic Profile*
Immuno Labs tTG - IgA
Price: $149
A
milk and
egg antibody profile
Price: $179
Includes Comprehensive
Metabolic Profile*
*
This is a free test that is offered when other tests are ordered. -
Comprehensive Metabolic Profile -14 includes liver, kidney, glucose,
and electrolytes. The CMP is a frequently ordered group of 14
laboratory tests that gives important information about the current status
of your kidneys, liver and electrolyte and acid/base balance as well as
your blood sugar and blood proteins. Abnormal results, and
especially combinations of abnormal results, can indicate a problem that
needs to be addressed. Glucose (diabetes testing Kidney(renal panel)
Liver panel (Hepatic) Electrolytes (*fasting required)
You must first order through
DIRECT LABS and receive the necessary requisition
prior to visiting a Patient Service Center (PSC). The PSC will
not draw your blood without the DLS paperwork and/or you could get billed
the much-higher "Patient Price" without it.
These are short non
comprehensive antibody panels.
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
Enterolab - Director, Dr. Kenneth Fine
10875 Plano Rd. Suite 123,
Dallas , Texas 75238
Phone 972 -686-6869
Website:
www.enterolab.com
Email: info@intestinalhealth.org
This is a home stool test.
This is not a comprehensive
antibody panel.
However, due to it's high sensitivity for gliadin and tTG, and
its' intestinal function
test it finds antibodies much more often than typical celiac panels.
No dr. script required.
Gluten Sensitivity Panel (GS) $249
Gene test alone $149 Egg, Soy and Yeast test $199
Gluten Sensitivity Panel with Milk and Gene test $369
Colitis test $49 (GS Panel also recommended)
Test kits available at
www.enterolab.com
This is a home test. Results
emailed to patient.
Email support available.
This stool panel is part of ongoing
announced but unpublished research, is claimed to be more sensitive than
blood, and includes an intestinal function
test.
Even though this
test panel checks only 2 of many possible antibodies, it has a MUCH
higher positivity rate than identical "celiac only" blood tests.
The sensitivity of this test is
presumed to be due to earlier presence of antibodies in stool versus blood.
However,
since only 2 of many possible gluten related antibodies are checked,
a negative test result does not rule out the presence of other possible
gluten related antibodies or necessarily indicate that the patient can safely
consume gluten. In other words, a positive is conclusive of an
immune reaction, a negative is inconclusive.
Intestinal villi biopsy is not
recommended by this lab unless there are other reasons to examine the
digestive tract and duodenum. These researchers believe damage may
occur in many places in the body including but not limited to the villi,
and this invalidates villi biopsy as a diagnostic gold standard.
This test is controversial,
but patient and even overall
professional confidence appears to have risen significantly over the past 8 years, despite lack of formal validation. Many
many patients find the test results match their experience.
See
www.enterolab.com
for essays which explain this research project.
*
The
gene test is a 1 part
test meaning it is not as detailed for a few patients for the HLA DQ 2
gene.
See this page (bottom) for explanation.
The specific HLA DQ alleles
of the patient are reported whether or not the patient possesses a gluten
syndrome gene.
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
Genova
Diagnostics (formerly
Great Smokies Laboratories)
63
Zillicoa St.
Asheville, NC, 28801
Telephone: (800)522-4762 Fax: (828)252-9303
www.genovadiagnostics.com
8 am -
6:30 pm EST, Monday - Friday,
This lab offers
gluteomorphin
and
casomorphin testing in
addition to tTG/gliadin antibodies.
Urinary Polypeptides panel
- Gliadomorphins or Gliadorphins,
(another term for
gluteomorphins)
Casomorphins
Support guide
here
Celiac Profile - Tissue
Transglutaminase IgA and IgG,
Adrenocortex Stress Profile
Acetaminophen derivatives
Total IgA
When IgA-tTG is positive,
testing for IgA-Anti-endomysial Antibodies (IgA-EMA) is routinely
performed.
 Clinicians also have the
option of testing two additional analytes;
- IgA Anti-gliadin Antibodies (IgA-AGA)
- IgG Anti-gliadin antibodies (IgG-AGA)
These antibodies can be performed as part of the initial diagnostic
evaluation, or on their own to monitor compliance to a gluten free diet.
Dr. script required.
See physician for pricing
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the gluten free
diet. They do NOT recommend villi biopsy unless there are other
reasons to examine the gut. They use other comprehensive blood test
panels to find multiple tissue and function damage instead of focusing on
only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
The
Great Plains Laboratory, Inc.
11813
West 77th Street
Lenexa, KS 66214 USA
Director: Dr. William Shaw Ph.D. Board certified Chemistry and
Toxicology
Phone:
1-800-288-0383 Local: 1-913-341-8949 Fax:
1-913-341-6207
www.greatplainslaboratory.com
email: customerservice@GPL4U.com
Informacion en Espanol:
sfeliciano@GPL4U.com
Check
website for customer service in other languages.
This lab offers
gluteomorphin
and
casomorphin testing.
Gluten/Casein Peptides Test
- Gliadomorphins or Gliadorphins,
(another term for
gluteomorphins)
Casomorphins (milk peptides similar to gluteomorphins)
Explanatory brochure
here
Price:
$110.00
Dr. script required.
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the gluten free
diet. They do NOT recommend villi biopsy unless there are other
reasons to examine the gut. They use other comprehensive blood test
panels to find multiple tissue and function damage instead of focusing on
only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
HealthLabs
Phone:
800-579-3914
Website:
www.healthlabs.com
This is a short, non
comprehensive antibody panel.
Celiac
Disease Antibody Screening Test Panel - $249
Gluten Allergy Test (IgG)
Visit
www.HealthLabs.com
for fast, private & affordable lab testing.
No Dr office visit
required.
1. Order your test. 2.
Visit a local lab. 3 Get your results within 3 business days.
Call 800-579-3914 and
mention www.GlutenSensitivity.net for a 25% discount on any test!
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
Immco
Diagnostics, Inc.
Vijay Kumar, PH.D. - President and CEO
60 Pineview Drive, Buffalo, NY 14228 USA
USA Phone: 800-537-8378 International
phone: 716-691-0091 Fax: 716-691-0046
Website:
www.immco.net
email: info@immco.net
This is a short, non
comprehensive antibody panel.
Gluten Sensitive Enteropathy (Celiac
Disease) Panel - $275
Gene test only - $350
Dr. script required
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
Kimball Genetics
101 University Blvd., Suite 350, Denver,
CO 80206
Tel. (800)-320-1807 (303)-320-1807
Fax (303)-388-9220
Hours 8:30 AM - 5:00 PM M-F
This is a genetics lab that also offers a celiac gene
test
and a short non comprehensive
gluten antibody panel.
Celiac
Disease DNA (gene) test - $395 (cash $355.50) Additional family members
$316.00
Celiac Disease Antibody Panel Celiac Disease DNA and Antibody Panel
Reports positive/negative
meaning "yes" or "no" for HLA DQ 2/8
Full HLA -
DQ2/8 genotype (specific alleles) available upon request by patient's physician
Kimball Genetics counselors are very informative and helpful.
*
Gene test is a 2 part test,
meaning the alpha and beta portions are performed. This means it is
more detailed for the HLA DQ 2 gene for a few patients.
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
Maryland, University of - University
of Maryland Center for Celiac Research
Medical Director: Dr.
Alesio Fasano M.D. Co Medical Director:
Carlo Catassi M.P.H.
Director: Pamela King
Dietitian: Pamela Cureton
20 Penn Street, Room S303B, Baltimore,
Maryland 21201
Celiac Appointment Line (410)-328-6749
(800)-492-5538
www.celiaccenter.org
This is a short, non
comprehensive antibody panel.
Celiac Disease Panel
Gene test
Intestinal duodenal biopsy
Skin Biopsy
This is a "villi damaged celiac disease" panel, recommended by
University of Maryland Center for Celiac Research. This is not
a commercial lab.
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
National Digestive Diseases
Information Clearinghouse
2 Information Way,
Bethesda, Maryland, 20892-3570
Tel: (800) 891-5389
Fax: (703) 738-4929
email:
nddic@info.niddk.nih.gov
http://digestive.niddk.nih.gov/ddiseases/pubs/celiac/#10
This panel focuses on villi
(celiac) damage only.
Celiac Disease Panel
Gene test
Intestinal duodenal biopsy
Skin Biopsy
This is a panel recommended specifically for "villi damaged celiac disease" by NDDIC.
NDDIC is not a lab.
The NDDIC website does not address the genetics of gluten reactivity. The NDDIC
is a service of
the National Institute
of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is
a part of the National
Institutes of Health (NIH) under the U. S.
Department of Health and Human Services.
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
Optimum Health Resource Laboratories
(formerly York Nutritional Laboratories)
2900 North 29th Avenue, Suite #205,
Hollywood, Fla, 33020 USA
Toll free
Tel: (888) 751-3388 Local (954) 920-3728
Fax: (954) 920-3729
www.optimumhealthresource.com
info@optimumhealthresource.com
This lab offers tests for
gliadin, wheat AND
gluten. Most
labs do not check gluten.
|
cdSCAN Celiac
Disease and
Gliadin Intolerance
Screening Profile
Tissue
Transglutaminase (tTG) - IgA, IgG, IgM
Autoantibody Gliadin - IgA
Rapid Test Kit $99
This test checks gliadin
(wheat), not gluten
Results available in
the home or Dr.'s office in
approximately 10 minutes.
|
saSCAN Secretory
IgA Food Intolerance Test
includes egg, gliadin, milk, and soy-$149
Specimen is mailed to lab for processing
This test checks
gliadin (wheat), not gluten
Specimen is mailed to lab for processing
IgG ELISA Food Intolerance Test
(96-food
panel) $379
This panel tests both gluten
AND gliadin (wheat) and 9 other grains in one place in the immune system (IgG).
Specimen is mailed to lab for processing
|
Optimum Research Lab tests all four IgG subsets - IgG-1, IgG-2,
IgG-3, IgG-4
Helpful information about Optimum Resource
Laboratories' Elisa tests
Validation related research
is posted on the website.
No dr. script required.
These are finger stick home tests. Results shipped
to patients with
guidebook and 1 year of
unlimited telephone and email support.
|
There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
|
Gluten Syndrome focused
researchers believe -
-
antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
-
there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
-
Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
|
|
Celiac (villi damage focused)
specialists believe -
|
|
|
Prometheus Laboratories
9410 Carroll Park Drive, San
Diego, CA 92121
Tel: (888) 423-5227
(858) 824-0895 Fax: (858) 824-0896
www.prometheuslabs.com
This is a short, non
comprehensive antibody panel.
Celiac Disease Panel $290
tTG-IgA
Screener only - $45
PRO-Genologix Celiac Genetics* testing $509
Individual tests available as follows: AGA - IgA or IgG
$35 Total IgA $25.00 EMA
$150
Dr. script required.
Will send transport kit to doctor or patient, no doctor account required.
35% discount for
cash (30 day) payment. Results sent to doctor.
*
Gene test is a 2 part test,
meaning the alpha and beta portions are both run. This gives more
detail regarding the HLA DQ 2 gene.
If the test is positive for
HLA DQ 2 or 8 it reports the specific alleles. If negative for HLA
DQ 2 or 8 it reports "yes" or "no" .
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There are two
major perspectives on the gluten syndrome vs. celiac disease that
involve how to test and interpret tests. |
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Gluten Syndrome focused
researchers believe -
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antibodies are conclusive
proof of immune reaction to gluten and indicate need for the
gluten free diet. They do NOT recommend villi biopsy unless
there are other reasons to examine the gut. They use other
comprehensive blood test panels to find multiple tissue and
function damage instead of focusing on only one tissue, (villi).
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there are many gluten related
peptides, such as gluteomorphins (also called glidorphins or
gliadomorphins) and gluten related antibodies, which may show up in any of several areas of the immune
system, IgA, IgG, or IgM, or in any of several mediums, such as blood,
saliva or stool, or urine in the case of gluteomorphin peptides. They test as many antibodies as necessary to find
the particular antibodies a patient may produce, with much higher rates of positivity than short panels yield. However, in the end they
consider even the most complete negative test panel necessarily
inconclusive since there are known peptides/antibodies for which there are no tests
at this time (this is uncommon).
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Dr Vojdani, Immunosciences
Laboratories, believes elevated tTG is sometimes but not always present in
a gluten related autoimmune reaction. Therefore he believes it
should be included in test panels but not used as a screener.
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Celiac (villi damage focused)
specialists believe -
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Disclaimer Text
Ó2006 - Gluten
Sensitivity |
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